Upstream
Part of speech: adjective
Definition: in a direction against the flow of a current or stream; upriver involving exploration and pre-production rather than refining and selling in the direction from the client to the server towards the leading end (5'end) of a DNA molecule
Part of speech: adverb
Definition: against the current
Example sentence: I needed to explain that Louisiana's coast accepts the drainage from two-thirds of the United States and, while the necessary levees constructed upstream have prevented floods, they have also contributed to problems downstream.
Upriver
Part of speech: adverb
Definition: towards the source of a riveragainst the current