Manuscript
Part of speech: adjective
Definition: Which is handwritten, or by extension typewritten, as opposed to mechanical reproduction
Part of speech: noun
Definition: A book, composition or any other document, (type)written by hand, not mechanically reproduced. A single, original copy of a book, article, composition etc, written by hand or even printed, submitted as original for (copy-editing and) reproductive publication.
Example sentence: In my office in Florida I have, I think, 30 manuscript piles around the room. Some are screenplays or comic books or graphic novels. Some are almost done. Some I'm rewriting. If I'm working with a co-writer, they'll usually write the first draft. And then I write subsequent drafts.
Holograph
Part of speech: noun
Definition: A hologram.A handwritten document, especially a letter, deed, or will, that is solely the work of the person whose signature it bears; a manuscript.