Tragedy
Part of speech: noun
Definition: A drama or similar work, in which the main character is brought to ruin or otherwise suffers the extreme consequences of some tragic flaw or weakness of character. The genre of such works, and the art of producing them. A disastrous event, especially one involving great loss of life or injury.
Example sentence: All women become like their mothers. That is their tragedy. No man does. That's his.
Calamity
Part of speech: noun
Definition: An event resulting in great lossThe distress that results from some disaster
Example sentence: The difference between a misfortune and a calamity is this: If Gladstone fell into the Thames, it would be a misfortune. But if someone dragged him out again, that would be a calamity.