Large
Part of speech: adjective
Definition: Of considerable or relatively great size or extent.
Example sentence: In matters of truth and justice, there is no difference between large and small problems, for issues concerning the treatment of people are all the same.
Significant
Part of speech: adjective
Definition: Signifying something; carrying meaning.Having a covert or hidden meaningHaving a noticeable or major effect; notableReasonably large in number or amountHaving a low probability of occurring by chance (for example, having high correlation and thus likely to be related).
Example sentence: Hospitality is central to the restaurant business, yet it's a hard idea to define precisely. Mostly, it involves being nice to people and making them feel welcome. You notice it when it's there, and you particularly notice it when it isn't. A single significant lapse in this area can be your dominant impression of an entire meal.